Limited independent prognostic value of MMP-14 and MMP-2 expression in ovarian cancer
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چکیده
منابع مشابه
Limited independent prognostic value of MMP-14 and MMP-2 expression in ovarian cancer.
BACKGROUND In cancer, various MMPs play a role in progression and metastasis and their overexpression generally indicates a poor prognosis. MMP-14 is the main activator of MMP-2 and both molecules play a role in normal ovarian follicular development. Earlier reports indicated a prognostic value for both MMP-14 and MMP-2 in ovarian cancer. This study was designed to determine the prognostic valu...
متن کاملImmunohistochemical expression of MMP-14 and MMP-2, and MMP-2 activity during human ovarian follicular development
BACKGROUND The aim of this study was to investigate the presence of MMP-14 and MMP-2 during human ovarian follicular development using immunohistochemistry, and the activity of MMP-2 in follicular fluid using zymography. METHODS Ovarian tissue collected from the archives of the Department of Pathology was examined and medical records and histopathology were reviewed. Follicular fluids were co...
متن کاملDifferential Associations of MMP-2 and MMP-14 with Stromal Amounts and T-lymphocyte Presence in Ovarian Cancer
Differential Associations of MMP-2 and MMP-14 with Stromal Amounts and T-lymphocyte Presence in Ovarian Cancer M Caroline Vos1*, Elise Bekers2, Brenda L den Oudsten3, Ella M. de Boed2, Anneke A M van der Wurff2, Toin H van Kuppevelt4, Katarina Wolf5 and Leon F A G Massuger6 1Department of Obstetrics and Gynaecology, ElisabethTweesteden Hospital, The Netherlands 2Department of Pathology, Elisabe...
متن کاملExpression of MMP-2, −7, −9, MT1-MMP and TIMP-1 and −2 has no prognostic relevance in patients with advanced epithelial ovarian cancer
Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are involved in tumor invasion, but their prognostic significance is still under discussion. We set out to analyze the epithelial and stromal expression of MMP-2, MMP-7, MMP-9, MT1-MMP, TIMP-1 and TIMP-2 in advanced epithelial ovarian cancers and to assess their prognostic value. A tissue microarray of malignant ovarian tumors...
متن کاملPrognostic value of MMP-9 in ovarian cancer: a meta-analysis.
OBJECTIVE Matrix metalloproteinase-9(MMP-9) plays an important role in tumor cell invasion. Although it has been studied frequently in ovarian cancer, its prognostic impact is still equivocal. The aim of this study was to more precisely estimate its prognostic significance. METHOD We searched Pubmed, Embase, OVID, Sciencedirect and CBM databases to identify eligible studies. Hazard ratios (HR...
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ژورنال
عنوان ژورنال: Diagnostic Pathology
سال: 2016
ISSN: 1746-1596
DOI: 10.1186/s13000-016-0485-3